3.33 out of 5 based on 6 customer ratings
(6 customer reviews)


The Neuropeptide Facial Cleanser from Perricone MD is formulated to restore aging skin. A combination of neuropeptides and DMAE cleanse, hydrate, and nourish the skin. The formula removes make-up and provides antioxidant protection. The Paraben-free formula is non-drying and gentle to use.

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The skin should be cleansed at least twice per day to maintain a healthy complexion. The Neuropeptide Facial Cleanser from Perricone MD has been touted by the brand as a “rich cleanser”. The company suggests that the Paraben-free, soap-free formula will help you achieve a youthful appearance using Neuropeptide technology.

The brand lists benefits such as soothing the skin, removing impurities, and antioxidant activity. The Neuropeptide Facial Cleanser has been described as a nourishing treatment that conditions and hydrates the skin without stripping it or drying it out. Perricone MD says the formula is gentle enough to be used around the eyes.

The skin care brand recommends that the Neuropeptide Facial Cleanser be applied to dry or damp skin. It can be massaged into the skin with circular movements and should be rinsed with warm water. While the facial cleanser is soap and Paraben-Free, it does contain fragrance which may be irritating for those with sensitive skin.

The Neuropeptide Facial Cleanser by Perricone MD contains DMAE and of course Neuropeptides. DMAE is considered Dr. Perricone’s signature patent innovation said to prevent the skin from losing elasticity while also correcting it. DMAE stands for dimethylaminoethanol, a science that performs as a stabilizer for the cell membrane, which Perricone MD suggests is a critical part of muscles contracting and tightening.

The Neuropeptides in the Facial Cleanser are supposed to reverse the signs of aging rapidly. Lines, wrinkles, and sagging, the brand claims will be quickly revived. For those of you who are looking for a cleanser that is formulated for oily or acne prone skin, Perricone notes that the formula is best suited for skin where the signs of aging are more evident. While some cleansers do provide exfoliation, Perricone exfoliation with the Neuropeptide Facial Cleanser is limited and company literature suggests trying some of their other products especially formulated for troubled areas.

6FL OZ/177ML

Ingredients: Cetearyl Alcohol, Polysorbate 60, Olea Europaea (Olive) Fruit Oil, Stearic Acid, Benzyl Alcohol, Phosphatidylcholine, Theobroma Cacao (Cocoa) Seed Butter, Dimethyl MEA (DMAE), Sorbic Acid, Disodium EDTA, Hydrolyzed Oat Protein, Magnesium Aspartate, Zinc Gluconate, Sodium Hyaluronate, Copper Gluconate, Acetyl Hexapeptide-8, Fragrance/Parfum 

6 reviews for Perricone-Neuropeptide-Facial-Cleanser

  1. 2 out of 5


    This product leaves my face clean, but there is so much fragrance it nearly makes me sick. Won’t reorder.

  2. 5 out of 5


    Confidence is not a trait I usually exude but I do love the way this facial cleanser works and makes me feel. It truly is refreshing.

  3. 4 out of 5


    I use this product morning and night. I follow with cold plasma and Perricone moisturizer. My skin looks and feels wonderful. I use several products from Perricone and enjoy them. Some of the products do not have the best smell but it is something I can live with.

  4. 5 out of 5


    Besides the good smell, it lathers great, and a little goes a long way. My skin always feels clean, but not stripped of moisture. It is gentle enough to use morning and night. I love this cleanser!!

  5. 3 out of 5


    This product did do a great job keeping my skin feeling soft, but I need something more geared towards acne control. This didn’t help me at all for that.

  6. 1 out of 5


    Did not like this product at all; it was sticky and did not leave me feeling clean.

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