Perricone MD Acyl-Glutathione Deep Crease Serum

Perricone MD Acyl-Glutathione Deep Crease Serum

3.5 out of 5 based on 8 customer ratings
(8 customer reviews)


A treatment serum that targets expression lines and creases using Acyl-Glutathione, a product that has been described as a “master antioxidant” by Perricone MD.

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Lines and wrinkles are not only caused by the natural process of aging but, they can also form as the result of repeated facial expressions. As the muscles are used frequently, deep beneath the surface of the skin, lines begin to form. Loss of elasticity as the skin ages, decreases its ability to bounce back from certain muscular movements. Lines and wrinkles around the mouth, forehead, between the eye brows and around the eyes will eventually settle in. Even how you lay on your pillow can cause the appearance of wrinkles on the face, and they can be difficult to treat. The Acyl-Glutathione Deep Crease Serum by Perricone MD formulated to treat lines caused by repetitive facial expressions.

Perricone MD claims that the Acyl-Glutathione Deep Crease Serum is a powerful solution that will treat the lines and creases caused by facial movements. The company claims to provide instant, visible results. The product is supposed to smooth out the lines and erase the creases in troubled areas of the face. The serum is supposed to even work on the lips.

The skin care brand describes its Acyl-Glutathione Deep Crease Serum as a “non-invasive” alternative for younger looking skin. Some of the benefits that the product claims to offer are: shallowing of creases, softening of lines, illuminating effects, and a reduction in the appearance of frown and laugh lines.

They key ingredient inside of the Perricone MD Acyl-Glutathione Deep Crease Serum is the Acyl-Glutathione itself. Described by the brand as a “master antioxidant”, the formula is said to slow down the aging process. The ingredient promises to restore firmness, and fight against the signs of aging.

Perricone MD media on the product suggests applying the serum twice daily after cleansing the skin. The serum should be massaged into the lines on troubled spots around the mouth, forehead, and between the eyebrows. After allowing the product to absorb, the company suggests following up with the brand’s Acyl-Glutathione.

1 oz/ 30 ML

Ingredients: Water/Aqua/Eau, Glycerin, Tetrahexyldecyl Ascorbate, S-Palmitoylglutathione, Isopropyl Palmitate, Squalane, Butylene Glycol, Cyclopentasiloxane, Cetearyl Alcohol, Glycolic Acid, Glyceryl Stearate, PEG-100 Stearate, Dimethicone, Dimethyl MEA, Cyclohexasiloxane, Ceteareth-20, Fragrance/Parfum, Phenoxyethanol, Zinc Gluconate, Magnesium  Aspartate, Caprylyl Glycol ,Phosphatidylcholine, Disodium EDTA, Citric Acid, Docosahexaenoic Acid, Sorbic Acid, Linalool, Copper Gluconate, Tetrapeptide-21, Citronellol, Sodium Hyaluronate, Geraniol, Limonene, Acetyl Hexapeptide-8, Pentapeptide-18, Citral.

8 reviews for Perricone MD Acyl-Glutathione Deep Crease Serum

  1. 5 out of 5



    This product is amazing! It truly does work! I bought it for the deep crease between my eyes and my forehead. I noticed a difference instantly! I highly recommend this! I wish the price tag wasn’t so big but I guess it’s a cheaper alternative to botox and fillers!

  2. 5 out of 5



    I use a lot of perricone MD products but this one is by far the best! I have some deep creases by my mouth and on my forehead which are now barely visible after using this for for two weeks. I was hesitant because of the price but ended up going for it and I can’t be happier. I currently seeing what other products are available in this line because I’m so obsessed!

  3. 1 out of 5


    Did not work for me

    I love the Acyl-Glutathione eyelid serum so thought this would work. I’ve seen no changes. I don’t have creases per se, I have a bit of droop at the ends of my mouth. Maybe this only works for deep grooves?

  4. 5 out of 5


    My () are gone

    I’m stunned it actually worked. I am getting light ( ) around my mouth, but they’re becoming more and more noticable. I’ve been using this for a week, and I see a huge difference. My forehead its not working as effectively, but they’re deeper and a different feeling skin.

  5. 4 out of 5


    Good product.

    I use the product before bed and in the morning. People have offered me comments, but I don’t know how true it is. I don’t see any improvements myself. I say I have a new skin regimen but they don’t believe me. Cons, dogs lick my face, like I’m food. What’s up with that?

  6. 2 out of 5


    Didn’t do anything for me

    I am a fan and long time user of Perricone products. But this one had no effect after nearly two months of use. I even called Perricone customer service to see if they had any ideas for why it wasn’t working. They said my method of using it was correct. I returned the unused portion to Sephora. I think Strivectin is better for the money.

  7. 5 out of 5


    Saw the differences immediately

    Very impressed with this product. I think it is better than the orginal AG. I use on my “11” wrinkles, forehead lines, even the outer corners of eyes! Saw immediate results. Also apply a thin layer over entire face and neck. Love this product!

  8. 1 out of 5


    Not a fan

    I have become a Perricone devotee since I began using the products last December. I have seen a total transformation of my skin, neck and chest as a result of the system.

    I bought this product in August looking to reduce the deep furrows next to my brows and reduce forehead lines.

    I have to say I’ve seen no positive results from this product. I would have returned it but waited too long for the 30 day Money back guarantee.

    Oh well…I’ll keep loving the rest of my products.

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